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中医药研究与应用2025年第1卷第3期第9-12页,pISSN 3080-7670、eISSN 3080-7689 发布者:Quest Press 发布日期:2026/7/1
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火针联合水杨酸对痤疮患者皮肤屏障功能及微生态的影响


夏辛

天津市滨海新区塘沽新港街社区卫生服务中心,天津,300450

摘要:痤疮是常见的毛囊皮脂腺慢性炎症性疾病,皮肤屏障功能受损、微生态失衡,都和它的发病有密切关系。现在临床上常用维A 酸、抗生素这类药物治疗,但会让皮肤出现干燥、刺激反应,还可能产生耐药性,这些药物对皮肤屏障和菌群的长期影响,还需要进一步研究。本文为了明确火针加水杨酸的综合疗法,对痤疮患者皮损恢复、皮肤屏障功能调节以及皮肤微生态改善的作用,选出符合要求的痤疮患者,随机分成联合治疗组和对照组,两组分别接受火针联合水杨酸治疗、常规药物治疗,之后对比两组患者治疗前后的皮损严重程度,检测经皮水分丢失率、角质层含水量、皮肤表面脂质等屏障功能相关指标,同时用高通量测序技术分析皮肤表面菌群的多样性,以及关键菌属的相对丰度变化。

关健词:火针;水杨酸;痤疮;皮肤屏障;微生态
The impact of fire needle therapy combined with salicylic acid on the skin barrier function and microecology of patients with acne

Xin Xia

Tianjin Binhai New Area Tanggu Xingang Street Community Health Service Center,Tianjin 300450,China

Abstract: Acne is a common chronic inflammatory disease of the hair follicle and sebaceous glands, closely related to impaired skin barrier function and microecological imbalance. Currently, clinical treatments commonly include medications such as retinoids and antibiotics, which can cause skin dryness, irritation, and possibly drug resistance. The long-term effects of these medications on the skin barrier and microbiota require further investigation. In this study, to clarify the combined therapy of fire needle therapy and salicylic acid on the recovery of skin lesions, regulation of skin barrier function, and improvement of skin microecology in patients with acne, eligible acne patients were selected and randomly divided into a combined treatment group and a control group. The two groups received fire needle therapy combined with salicylic acid treatment and conventional drug therapy, respectively. Subsequently, the severity of skin lesions before and after treatment was compared between the two groups. Barrier function-related indicators such as transepidermal water loss rate, stratum corneum moisture content, and skin surface lipids were measured. High-throughput sequencing technology was used to analyze the diversity of skin surface microbiota and the relative abundance changes of key bacterial genera.


Keywords : Fire needle;Salicylic acid;Acne;Skin barrier;Microecology


参考文献
[1] 余凯琦,严檬,傅贝琳,韩铝洲,熊梦燎.胡氏消痤汤联合火针治疗肺胃湿热型痤疮临床研究[J].新中医,2026(06):111-112.
[2] 刘骏颖.维生素B_6 联合盐酸多西环素治疗玫瑰痤疮的临床效果及对皮肤屏障的影响[J].医学信息,2026(05):152-161.
[3] 杨舟,杨秀敏,金星姬,王晶,张海红,周曼婷,李承新,林碧雯.30%复合酸与30%水杨酸治疗轻中度痤疮的临床疗效及不良反应比较分析[J].中国美容医学,2026(03):183-188.
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